The Sex Glands
The glands of sex serve a double function:
they provide the necessary materials for reproduction of the human being, the
male sex cell uniting with the female sex cell; they also provide material which
goes directly from the glands into the blood, and which determines the nature of
the growth of the body. If the amount of the material secreted by the gland into
the blood is insufficient, definite changes will take place in the body
inclining towards the female side if the male sex issue is insufficient, and to
the masculine side in the woman if the female sex tissue is
insufficient.
A deficiency of the male
sex material may result from absence or destruction of the gland or from failure
to function, in cases where the pituitary gland does not produce the trophic
hormone that stimulates the male sex gland. Again, there may be disturbance of
the function of the cells ithin the gland, without actual destruction of the
tissue.
A deficiency of male glandular material varies in its effects
according to the age at which it occurred. If the material is completely absent,
the condition called "eunuchism" is developed; this usually refers to a complete
loss. When the loss of sexual gland function takes place before the time of
maturation into an adolescent, a deficiency is shown in growth. The skin is
delicate; the hair that ordinarily covers the surface of the body of the male is
absent; there also may be exaggerated length of the arms and legs with broad
hips and a tendency towards the development of a "pot belly"; sometimes also the
breast of the male will enlarge.
Sex Gland Deficiency
If a
deficiency of sex gland hormone takes place after adolescence, the changes
include a retardation of the growth of the beard and thinning of the skin with
lessened pigmentation,
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perhaps also a diminution or complete absence of hair under the arms and around
the sex organs. Interestingly there is also a failure to grow hairs on the ear,
which is rather typical of men past twenty-five or thirty years of
age.
After men have matured and have reached the age of forty-five or
fifty, they do not usually suffer the changes that come on in women about the
same time and which are known as the "climacteric." The specialists believe that
this is due to the fact that the sexual function of men declines gradually,
rather than abruptly as occurs with women. The changes that occur in men are not
visible in any way in the structure of the body, since this has been well
established by the age of forty-five, but are more definitely related to the
functions of the body and to symptoms that manifest themselves often in the
nervous system.
When there is an absence of sex gland material, as is
determined by some of the signs that have been described, administration of the
artificially-prepared material is now possible, due to the development of the
glandular material called testosterone. The amount of the material to be given
and the duration of the time over which it is to be given depends,
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on the condition of the patient, whom the doctor watches carefully. Actually
there may be the growth of pimples, and in the case of women a tendency towards
a masculine appearance from too much sex gland material. There are also effects
on the handling of salt and water by the body. It has been established that
excesses of testosterone, particularly in young boys, may result in difficulty
in the development of sperm cells necessary for reproduction.
Excessive
Male Sex Gland Action
Excessive production of male sex hormones is
observed in men particularly when there are tumors of the male sex glands. Such
tumors have been observed by physicians in many cases. Occasionally excessive
growth of tissue of the anterior pituitary gland or in other portions of the
brain may stimulate the sex glands excessively, so that large amounts of male
sex hormones are thrown into the circulation. The manifestations of excessive
secretion vary with the time when the condition occurs. If it comes on before
the young boy has reached puberty, the excessive gland material may cause
puberty to come on much sooner than normally. Associated with this precocious
pseudo-puberty is a too-early development of all of the male sex
characteristics, including excessive growth of the sex organs, the development
of a large amount of hair around the sex organs and under the arms, and, even in
little boys, the development of a beard and a mustache, a deep voice and similar
conditions. Physicians have observed that excessive amounts of male sex gland
material will cause increased secretion of the oil glands in the skin, and
associated acne is not uncommon. There may often also be changes in the growth
of the skeleton. In this instance, the trunk, the arms and legs are found to be
short due to too-early closure of the points from which the bones grow.
Associated also with these developments may be excessive and definitely
increased muscular development and strength; the so-called "infant Hercules."
If the excessive secretion of glandular material comes on after the body
has passed puberty,
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masculine character. Obviously, the skeleton has already developed so that there
cannot be effects on the skeleton.
The only known treatment for
excessive activity is removal of the tumor which is responsible. Removal of
portions of the tumor or of all of the tumor would naturally result in lessening
the amount of sex gland material. This can be measured by chemical study so that
the return to normal can be definitely known. If, however, the tumor material
should return and grow again, the excess of glandular secretion can be
determined through examination of the urine. In this way the physician can trace
the progress of the tumor growth.
Fortunately tumors of the male sex
gland are relatively rare. Doctors believe that these tumors occur more often
when there has been failure of the male sex gland to descend into the sac,
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before ten or eleven years of age, if not sooner. Experience has shown that the
best thing to do whenever there is any tumor of this area is to have it removed
by surgery as soon as possible. If the tumor is not a malignant tumor, it is in
any event a threat. If, however, it is a malignant tumor, the growth quite
certainly threatens life itself. In fact, so definitely is that threat known
that it has become customary to use the X-ray to irradiate the area from which
the tumor has been removed, to make certain that all excessive action has been
stopped.
If the male sex gland is retained and fails to descend into the
sac, its function may be destroyed by the heat to which it is subjected in the
body.
Failure of sexual gland function causes psychosexual changes in the
males, including loss of initiative and drive. Some psychiatrists feel this
effect is wholly mental and results from a feeling of inferiority because the
person knows of his deficiency.
Sexual precocity associated with excess
of testosterone or androsterone has also been noted with adrenal and pituitary
gland tumors.