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reticulum proliferation and expansion
ferfewdfsdf 发表于 2012/3/10 10:50:00
Skin the concept
skin wrapped around the body, contact with the external environment, to protect, feeling, regulating body temperature, secretion and excretion. It protects the body organs and tissues from the external environment in the mechanical, physical, the damage of harmful chemical and biological factors, to prevent the loss of the organization a variety of nutrients, electrolytes and water. skin contains many sensory nerve endings, can sense cold, heat, pain, touch and pressure stimulation of the skin through the sebum excretion of metabolites of the body with sweat. the thickness of the skin with the parts, and general between in 0.5mm4mm, points the outer and inner layers of the epidermis and dermis of epidermal epithelial cells of various shape, size constitute these cells by primary outside goes on to differentiate into spinous layer, the grain layer, the transparent layer and the stratum corneum, this process is the diagonalization process, the transparent layer exists only in charge of extension parts. dermis is divided into the depth of two layers, the dermal fat and other organizations. < br> the scar
scar, namely what we call the scar is a general concept, it is collectively referred to as the skin after various traumas caused by the appearance of normal skin shape and histopathological changes. it is the surface of the body naturally healing process of a normal, inevitable physiological responses, the inevitable result of the wound healing process, scar tissue is a do not have normal skin, loss of normal vitality, abnormal sound organization which not only destroyed the surface America has also hampered the physiological function of tissues and organs, or even disability.
scar causes
of Chinese medicine scar formation is divided into external and internal factors external factors are the external factors acting on the surface of the body,mbt shoes cheap, such as trauma, wound foreign body, wound infection after surgery, the surface tension is too large, burns, burns damage the dermis and subcutaneous tissue to scar formation. internal refers to the body's own qualities, race, individual quality, metabolic status, age and nutritional status, other diseases pigment deposition conditions and the formation of
scar the mechanism
studies have shown that fibroblast cells, cytokines, extracellular matrix of the three scar formation plays an important role in scar morphology of the stratum corneum thin, uneven distribution of fibrous, some parallel to each other, some woven into nets, a small gap of the structure loose; the epidermis and dermis occupies a rich capillary, common at 40 magnification in a field of view 10mm13 capillary cross-section of the root; prickle cell layer is more than 13 --- 15 irregular prickle cells; into fiber cells, vascular endothelial cells TGFmm1 (transforming growth factor), and collagen deposition in the scar tissue within the dermis see various forms of fibroblasts and myofibroblasts in a large number of disorganized, coarse collagen fibers and fibrous tissue with rhabdoid features; scar into active fibroblasts and collagen secretion of strong mast cell number, function, these changes with the scars gradually The maturing mitigation; that scarring, contracture, and fibroblast cells, cytokines, myofibroblasts, vascular endothelial cell proliferation and function is active, a large number of collagen deposition and changes are closely related.
by various periods dynamic changes in hypertrophic scars and found that VEGF (vascular endothelial growth factor) with the development of hypertrophic scars, the expression level to further increase the peak, the expression of in 4mm6 a hypertrophic scars. of PDGF (platelet derived growth factor) and its receptor significantly enhanced performance in the scar tissue
This study also showed that post-traumatic skin fibroblasts, the rough endoplasmic reticulum proliferation and expansion into the capsule, the cytoplasm microfilaments and microtubules increased in the granulation tissue, and as early as the mid-proliferative scar muscle fibroblast content increases, the actin filaments arranged along the shrinkage direction equal systolic function closely near the collagen fibers, tight at this time posted in the muscle fibroblast cell surface collagen fibers change curved or spiral of, fibroblasts continue synthesis of collagen and matrix, the formation of a rigid structure, contracture hardened scar tissue, leading to local deformities and functional barriers around the contraction state of muscle fibroblast cells scar tissue mast cell density increases, the ammonia of 5 - hydroxytryptamine, histamine increased the blood vessels, blood supply,Nike Air Max TN, inflammatory cell infiltration, tissue ischemia and hypoxia, decreased collagenase activity, collagen degradation imbalance, damage the organization itself healing; the 1 - 3 by the red point of light shaped into a bright red flakes, surface rough, induration, itching obvious; scars continue to grow of 3 - 6 months, the color changed from red to purple, the surface revealed capillaries, scars of a few millimeters thick, hard texture, inelastic, a year or more scars mature, become light brown, the surface of blood vessels disappear, itching symptoms, scars soften thin, but the dysfunction is not easy to improve. < br> the scars diagnosis
etiology: scar, multiple trauma, surgery, burns, burns, chemical injury, vaccination,nike dunks high, infection, acne, insect bites and other skin damage.
symptoms: scarring in the active proliferation of multi-local irritating itching, pain, rainy days, and eating spicy food after the increase, accompanied by severe local dysfunction
forms: strip, circular, oval, irregular, one or more connected into the film, webbed, the bridge above the skin or sunken skin color: a little red, pink, red, purple, crimson, or depigmentation.
texture: soft, slightly hard, hard, hard, or from the the blisters
thickness : thin, thin, slightly thick, thick, obvious thickening.
parts: one or more.
: observe whether more than the original injury the range
temperature: a large area of ??hypertrophic scars can be reduced skin cooling effect, affect the ability to regulate temperature, there
elevated body temperature.
malformations: the scar to the body caused by dysfunction the situation
complications: with or without infection, ulcers, leakage Road and crypt
The physical scars: the performance of surface scars after wound healing is increasing steadily, not only affect the appearance, and local pain, itching, redness and swelling in the joints hinder movement
above conditions have to be diagnosed scar.
, scar classification < br> from medical records and histological classification: normal skin scars, hypertrophic scars, keloids three
2 The clinical manifestations and organizations learn to change the classification
A. superficial or flat scars
B. cords or contracture by scar
C. webbed scar
D. pitting by scar
E. bridging and mastiff-like scar
F. atrophic scars
G. Keloids and scarring the H. depigmentation cancer
scar.
scars course and outcome of
scars from skin lesions began to peak three months for the acute proliferative phase a 3mm6 months of general 1mm2 natural maturation also 10 years is still hyperplasia up to 19 years is still in the proliferative phase. status quo

present treatment of scar scar crowd is a huge group in the present, especially in recent years a variety of accidental injuries a substantial increase, and the scars are mostly in the exposed parts of the formation of scar surgery and cosmetic plastic surgery is also growing, According to authoritative statistics, Asians accounted for 85.68% of physical scars,leather belts, and China is high physical scars country, the physical scars crowd accounted for more than 85%, scar crowd of more than 90%. the treatment of scars at home and abroad using local drug closed, the surgical removal of skin grafting, crystal wear scar surgery, balloon dilatation, immunotherapy (vascular endothelial growth factor (VEGF) antibody injection therapy) gene therapy , radiation therapy, compression therapy, hormone therapy, silicone and other therapies. in clinical practice is not very mature, efficacy remains to be seen, some required a long time, pain, and many of them not working well. Chinese medicine as early as 2,000 years discussed on the formation and treatment of scars, the the Neijing camp gas not from the inverse in the flesh, is born bloated pathogenic cold off the meridian into the blood weeping, blood weeping barrier, different Wei gas owned by the, not only repeated, so carbuncle Wei, go hand in hand up and down, that the wing guard, pass the meridian, Rong solid on the outside. Ying Qi and by the gas barrier can not wing solid on the outside, and finally made the race and quality, individual quality, metabolic status, age, and nutritional status, other diseases pigmentation related. external refers to external factors in the surface of the body, such as caused by trauma, hematoma, wound, foreign body, infection after surgery, the surface

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